The following partnerships are focused on the discovery and development of novel Anticalin therapeutics
On February 9, 2018, Pieris and Seattle Genetics announced a multi-program immuno-oncology alliance with the goal of developing targeted bispecific immuno-oncology therapies. The collaboration leverages the expertise and core technologies of both companies to develop novel Antibody-Anticalin fusion proteins. Pieris' proprietary suite of agonistic costimulatory Anticalin proteins, when fused to a tumor-targeting antibody, can activate the immune system preferentially in the tumor microenvironment. Seattle Genetics, through its industry-leading work in the field of antibody-drug conjugates (ADCs), has a substantial portfolio of cancer targets and tumor-specific monoclonal antibodies from which programs will be selected for the collaboration. The bispecific drug candidates in this alliance will be designed to enable the patient's immune cells to specifically attack tumors. The companies will pursue multiple Antibody-Anticalin fusion proteins during the research phase, and Seattle Genetics has the option to select up to three therapeutic programs for further development. Prior to the initiation of a pivotal trial, Pieris may opt into global co-development and US commercialization of the second program and share in global costs and profits on a 50/50 basis. Seattle Genetics will solely develop, fund and commercialize the other two programs.
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On May 3, 2017, Pieris and AstraZeneca announced a broad strategic collaboration in the local delivery of targeted biologics in respiratory disease. The collaboration seeks to address a significant unmet clinical need by advancing several novel inhaled biologic molecules leveraging the unique properties of Pieris' Anticalin proteins to yield improvements in convenience, cost of therapy, safety and efficacy. Under the terms of the collaboration, Pieris and AstraZeneca will pursue up to five therapeutic programs, led by Pieris' lead respiratory program, PRS-060, a first-in-class inhaled IL4RA antagonist for the treatment of asthma. Pieris will be responsible for advancing PRS-060 into clinical trials in 2017 and will conduct a phase 1 trial in healthy volunteers. The parties will collaborate thereafter to complete a phase 2a clinical trial in asthma patients while AstraZeneca will fund all development until this stage. After completion of the phase 2a, Pieris has the option to co-develop and subsequently co-commercialize the program in the United States with AstraZeneca. For the other four programs, Pieris will be responsible for the initial discovery of novel Anticalin proteins after which AstraZeneca will take the lead on continued development. Pieris has the option to co-develop two of these programs at a pre-defined preclinical stage and would also have the option to co-commercialize these programs in the United States, while AstraZeneca will be responsible for development and commercialization of the other programs worldwide.
On January 05, 2017, Pieris and Servier, the second largest independent international pharmaceutical company headquartered in France with annual sales of more than EUR4 billion, entered into a broad strategic co-development alliance in Immuno-Oncology. Under the collaboration, Pieris and Servier will initially pursue five bispecific therapeutic programs, led by Pieris’ preclinical PRS-344 program, a 4-1BB/PD-L1 bispecific. The four additional committed programs may combine antibodies from the Servier portfolio with Anticalin proteins based on Pieris’ proprietary platform to generate highly innovative immuno-oncology bispecific drug candidates. The alliance may be expanded to a total of eight immuno-oncology programs and Pieris has the option to co-develop and retain full commercial rights in the United States for four of these programs. Pieris has already exercised its opt-in right to co-develop and retain U.S. rights for one of these programs: PRS-344.
On February 27, 2017, Pieris and ASKA Pharmaceutical, an independent Japanese pharmaceutical company with annual sales of approximately $400 million, entered into an option agreement for Pieris’ anemia program PRS-080. Under the terms of the agreement, ASKA has the exclusive option to license commercial rights to PRS-080 in Japan and certain other Asian countries after the completion of the planned Phase 2a study conducted by Pieris, which is scheduled to be completed in H2 2017.