Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Operating activities:    
Net loss $ (24,698) $ (15,072)
Adjustments to reconcile net loss to net cash provided by operating activities:    
Depreciation 367 405
Stock-based compensation 4,260 3,665
Deferred rent expense 853 0
Other 90 (376)
Changes in operating assets and liabilities (19,365) 19,370
Net cash (used in) provided by operating activities (38,493) 7,992
Investing activities:    
Purchases of property and equipment (1,286) (1,133)
Proceeds from maturity of investments 61,767 64,490
Purchases of investments (48,762) (67,015)
Net cash provided by (used in) investing activities 11,719 (3,658)
Financing activities:    
Proceeds from exercise of stock options 218 983
Proceeds from exercise of warrants 105 314
Proceeds from employee stock purchase plan 178 0
Issuance of common stock, net of issuance costs 0 47,207
Net cash provided by financing activities 501 48,504
Effect of exchange rate change on cash and cash equivalents (2,526) (1,234)
Net (decrease) increase in cash and cash equivalents (28,799) 51,604
Cash and cash equivalents at beginning of period 74,867 37,878
Cash and cash equivalents at end of period 46,068 89,482
Supplemental cash flow disclosures:    
Cash paid for income taxes 0 902
Net unrealized gain on investments 469 1,096
Property and equipment included in accounts payable $ 198 $ 222