Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
At the market offering
Private Placement
Convertible  preferred shares
Convertible  preferred shares
At the market offering
Convertible  preferred shares
Private Placement
Common shares
Common shares
At the market offering
Common shares
Private Placement
Additional paid-in capital
Additional paid-in capital
At the market offering
Additional paid-in capital
Private Placement
Accumulated other comprehensive income (loss)
Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2019       11,000     55,212,000              
Balance at beginning of period at Dec. 31, 2019 $ 51,352     $ 0     $ 55     $ 227,468     $ (1,995) $ (174,176)
Increase (Decrease) in Stockholders' Equity                            
Net loss (37,230)                         (37,230)
Foreign currency translation adjustment 1,630                       1,630  
Unrealized gain on investments 70                       70  
Stock based compensation expense 5,090                 5,090        
Issuance of common stock resulting from exercise of stock options (shares)             149,000              
Issuance of common stock resulting from exercise of stock options $ 291                 291        
Issuance of common stock resulting from purchase of employee stock purchase plan shares (shares) 69,544           70,000              
Issuance of common stock resulting from purchase of employee stock purchase plan shares $ 200                 200        
Issuance of common stock resulting from exercise of warrants (shares)             0              
Issuance of common stock resulting from exercise of warrants 0                 0        
Preferred stock conversion (shares)       3,000     (3,000,000)              
Preferred stock conversion 0           $ (3)     3        
Issuance of common stock pursuant to offering (in shares)         0     3,571,000            
Issuance of common stock pursuant to offering value   $ 9,624           $ 4     $ 9,620      
Balance at end of period (shares) at Dec. 31, 2020       14,000     56,003,000              
Balance at end of period at Dec. 31, 2020 31,027     $ 0     $ 56     242,672     (295) (211,406)
Increase (Decrease) in Stockholders' Equity                            
Net loss (45,738)                         (45,738)
Foreign currency translation adjustment 1,124                       1,124  
Stock based compensation expense 5,215                 5,215        
Issuance of common stock resulting from exercise of stock options (shares)             482,000              
Issuance of common stock resulting from exercise of stock options $ 1,024                 1,024        
Issuance of common stock resulting from purchase of employee stock purchase plan shares (shares) 64,257           64,000              
Issuance of common stock resulting from purchase of employee stock purchase plan shares $ 165                 165     0 0
Issuance of common stock resulting from exercise of warrants (shares)             1,391,000              
Issuance of common stock resulting from exercise of warrants 837           $ 1     836        
Issuance of common stock resulting from conversion of preferred stock (shares)       (4,000)     3,812,000              
Issuance of common stock resulting from conversion of preferred stock 0     $ 0     $ 4     (4)        
Preferred stock conversion (shares)       5,000     (5,000,000)              
Preferred stock conversion 0     $ 0     $ (5)     5        
Issuance of common stock pursuant to offering (in shares)         0 0   8,180,000 7,290,000          
Issuance of common stock pursuant to offering value   $ 38,188 $ 18,913         $ 8 $ 8   $ 38,180 $ 18,905    
Balance at end of period (shares) at Dec. 31, 2021       16,000     72,222,000              
Balance at end of period at Dec. 31, 2021 $ 50,755     $ 0     $ 72     $ 306,998     $ 829 $ (257,144)