Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Operating activities:    
Net loss $ (10,348) $ (8,714)
Adjustments to reconcile net loss to net cash provided by operating activities:    
Depreciation 166 134
Stock-based compensation 1,290 1,004
Other (298) 8
Changes in operating assets and liabilities (5,918) 38,907
Net cash (used in) provided by operating activities (15,108) 31,339
Investing activities:    
Purchases of property and equipment (121) (414)
Proceeds from maturity of investments 2,842 3,600
Purchases of investments (8,037) (11,479)
Net cash used in investing activities (5,316) (8,293)
Financing activities:    
Proceeds from exercise of stock options 0 826
Proceeds from exercise of warrants 0 126
Issuance of common stock, net of issuance costs 0 47,207
Net cash provided by financing activities 0 48,159
Effect of exchange rate change on cash and cash equivalents (2,349) 438
Net increase in cash and cash equivalents (22,773) 71,643
Cash and cash equivalents at beginning of period 74,867 37,878
Cash and cash equivalents at end of period 52,094 109,521
Supplemental cash flow disclosures:    
Net unrealized gain (loss) on investments 330 (697)
Property and equipment included in accounts payable $ 0 $ 65